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CNS
drug delivery and tissue engineering
My research is motivated by the desire to create safer and more effective medical and surgical therapy. I focus on tissue engineering and on creating better methods for drug delivery.
My group has developed technology based on the use of bio-compatible polymeric materials for the controlled delivery of drugs, proteins, and genes. We have also developed new polymeric materials that influence the growth and assembly of tissues.
However, even better than treating disease is to prevent disease from occurring in the first place. My intent, therefore, is to develop the most economical, transportable, and accessible methods for disease prevention.
I am also committed to training a new generation of chemical and biomedical engineers. I believe in providing a stimulating and collaborative environment that promotes the free exchange of ideas and encourages creative blending of technology and modern biological science.
Recent publications:
Shen H, Tan J, and Saltzman WM. Surface-mediated gene transfer from nanocomposites of controlled texture, Nature Materials, in press.
Stroh M, Williams R, Zipfel W, Webb WW, and Saltzman WM. Multiphoton Microscopy Guides Neurotrophin Modification with Poly(ethylene glycol) to Enhance Interstitial Diffusion, Nature Materials, in press.
Luo D, Han E, Belcheva N, and Saltzman WM. A self-assembled, modular DNA delivery system mediated by silica nanoparticles, Journal of Controlled Release 95: 333-341 (2004)
Tan J and Saltzman WM. Biomaterials with hierarchically defined micro- and nano-scale structure. Biomaterials 25: 3593-3601 (2004).
Keegan ME, Whittum-Hudson JA, and Saltzman WM. Biomimetic design in microparticulate vaccines. Biomaterials 24:4435-4443 (2003)
Stroh M, Zipfel W, Williams RM, Webb WW, and Saltzman WM. Diffusion of nerve growth factor in rat striatum as determined by multiphoton Microscopy, Biophysical Journal, 85:581-588 (2003)
W.M. Saltzman and W.L. Olbricht,"Building drug delivery into tissue engineering," Nature Reviews Drug Discovery, 1, 177-186 (2002)
J. Tan, H. Shen, and W.M. Saltzman,"Micron-scale positioning of features influences the rate of polymorphonuclear leukocyte migration,"Biophysical Journal, 81, 2569-2579 (2001)
M.J. Mahoney and W.M. Saltzman,"Transplantation of brain cells assembled around a programmable, synthetic microenvironment,"Nature Biotechnology, 19, 934-938 (2001).
Mark.Saltzman@yale.edu
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