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CELLULAR AND MOLECULAR PHYSIOLOGY:
FROM FUNDAMENTAL MECHANISMS TO HUMAN DISEASE
C&MP 560b/MCDB 560b/MCDB
415
Spring Semester
Course Listings:
Cellular and Molecular Physiology: C&MP 560b
Molecular
and Cellular Developmental Biology: MCDB 415b/560b
Classes:
MWF 9:30-10:20 am
Location: Room: ML 104, Mason Laboratory, 9
Hillhouse Avenue
Course Directors
Michael Caplan, Professor,
Cellular and Molecular Physiology
Emile Boulpaep, Professor, Cellular and
Molecular Physiology
Instructors
Emile Boulpaep, Professor,
Cellular and Molecular Physiology
Michael Caplan, Professor, Cellular and
Molecular Physiology
Barbara Ehrlich, Professor, Pharmacology & Cellular
and Molecular Physiology
Bliss Forbush, Professor, Cellular and Molecular
Physiology
Fred Sigworth, Professor, Cellular and Molecular Physiology
Peter
Takizawa, Assistant Professor, Cell Biology
Course Description Every
cell devotes an enormous fraction of its resources to controlling the movement
of substances into and out of its cytoplasm. The sequencing of the human genome
has revealed that as many as 1,000 to 2,000 of our genes (3-4% of the genome)
encode proteins that function in membrane transport. This course will focus on
understanding the nature of membrane transport processes at the cellular, molecular,
biophysical and physiologic levels. Students will learn about the different classes
of molecular machines that mediate membrane transport and their mechanisms of
action. Emphasis will be placed upon the relationship between the molecular structures
of transport proteins and their individual functions. The interactions among transport
proteins in determining the physiologic behaviors of cells and tissues will also
be stressed. Molecular motors will be introduced and their mechanical relationship
to membrane transport proteins will be explored. Students will read papers from
the scientific literature that establish the connections between mutations in
genes encoding transport proteins and a wide variety of human genetic diseases.
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