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Cellular and Molecular Physiology Courses
C&MP
520a
Current Perspectives in Physiology
David Zenisek
Fall term
course
Course description C&MP
550a
Physiological Systems
Emile Boulpaep, Mark Saltzman
Fall
term course
course description
C&MP
560b
Cellular and Molecular Physiology: Molecular Machines in Human Disease
Emile Boulpaep,Michael Caplan,
Spring term course
course
description
C&MP
710b
Electron Cryo-Microscopy for Protein Structure Determination
Fred Sigworth, Vinzenz Unger
Spring term course
course
description
Course
Descriptions
C&MP
520a
Current Perspectives in Physiology
David Zenisek
This
seminar course explores a diverse range of current topics in physiology, emphasizing
readings and discussions of recent primary literature. A variety of expert physiologists
present topics such as structural biology, membrane transport, signal transduction,
sensory systems, exercise physiology. Instructors guide the discussion regarding
the background, the experiments, the methods, and most importantly the impact
of relevant research papers. The aim of the course is to understand how physiological
approaches integrate the study of organismal function from genes, to systems,
to behavior and disease.
Fall term course.
Tuesday, Thursday. 2:30-3:45
p.m.
Requirements and Speaker schedule
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C&MP
550a
Physiological Systems
Emile Boulpaep, Mark Saltzman
We develop a foundation in human physiology, the regulation of homeostasis, and
the biophysical properties of cells, tissues and organs. Basic concepts in cell
and membrane physiology are synthesized through exploring the function of skeletal,
smooth, and cardiac muscle. Regulation of cardiac output, blood flow, and vascular
exchange are integrated in light of exercise performance. Respiratory physiology
explores the mechanics of ventilation, gas diffusion, and acid-base balance. Renal
physiology explores the formation and composition of urine and the regulation
of electrolyte, fluid, and acid-base balance. Organs of the digestive system are
developed from the perspective of substrate metabolism and energy balance. Hormonal
regulation is applied to metabolic control and to calcium, water, and electrolyte
balance. The special senses are considered in light of signaling processes inherent
to the nervous system. Weekly discussion sections provide a forum for in-depth
exploration of topics. Graduate students evaluate research findings through literature
review and weekly meetings with the instructor.
(also ENAS 350a/550a,
MCDB 310a/550a)
Fall term course.
Monday,
Wednesday, Friday. 9:30-10:20 a.m.
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C&MP 560b
Cellular
and Molecular Physiology: Molecular Machines in Human Disease
Emile Boulpaep,Michael
Caplan,Mark Mooseker, Fred Sigworth
This course focuses on understanding
the processes that transfer molecules across membranes at the cellular, molecular,
biophysical, and physiologic levels. Students learn about the different classes
of molecular machines that mediate membrane transport, generate electrical currents,
or perform mechanical displacement. Emphasis is placed upon the relationship between
the molecular structures of membrane proteins and their individual functions.
The interactions among transport proteins in determining the physiologic behaviors
of cells and tissues are also stressed. Molecular motors are introduced and their
mechanical relationship to cell function is explored. Students read papers from
the scientific literature that establish the connections between mutations in
genes encoding membrane proteins and a wide variety of human genetic diseases.
Note:
For undergraduates interested in taking this course, it is recommended after MCDB
205b or MCDB 310a or equivalent.
(also
ENAS 570) Spring
term course.
Monday, Wednesday, Friday 9:30-10:20 a.m
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C&MP
710b
Electron Cryo-Microscopy for Protein Structure Determination
Fred Sigworth, Vinzenz Unger
Understanding cellular function requires
structural and biochemical studies at an ever increasing level of complexity.
The course is an introduction into the concepts and applications of high-resolution
electron cryo-microscopy. This rapidly emerging new technique is the only tool
known to date that allows biological macromolecules to be studied at all levels
of resolution ranging from their cellular organization to near atomic detail. Requirements:
No specific requirements. However, parts of the course deal with diffraction theory
and physical principles of image formation. Therefore, knowledge of calculus and
basic physics are advantageous.
(also MB&B 710b4)
Spring term course. Offered second half of term.
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