Matthew W. State, M.D., Ph.D.

Director, Program on Neurogenetics
Co-Director of the Medical Genomics program in the Center for Human Genetics and Genomics
Harris Associate Professor of Child Psychiatry and Genetics

Research Interests

My research focuses on identifying and characterizing genes and genetic mechanisms involved in neuropsychiatric and developmental disorders of childhood. Currently the lab is focused on Tourette syndrome (TS), Autism and related pervasive developmental disorders, mental retardation, and structural abnormalities of the developing central nervous system. We use parametric linkage analysis in consanguineous families, traditional and molecular cytogenetics as well as array-based copy number analysis in our gene discovery efforts.

Recent Publications

• State MW, Greally JM, Cuker A, Bowers PN, Henegariu O, Morgan TM, Gunel M, DiLuna M, King RA, Nelson C, Donovan A, Anderson GM, Leckman JF, Hawkins T, Pauls DL, Lifton RP, Ward DC (2003). Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proceedings of the National Academy of Sciences of the United States of America 100: 4684-9
• Fernandez T, Morgan T, Davis N, Klin A, Morris A, Farhi A, Lifton RP, State MW (2004). Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p- syndrome. American Journal of Human Genetics 74:1286-1293
• Nahad, B, Seker A, Gulcu B, Ozturk A, Finberg K, Hawkins A, DiLuna M, Chamberlain A, State M, Lifton R, Gunel M (2004). Mapping a Mendelian form of intercranial aneurysm to 1p34.3-36.13. American Journal of Human Genetics 76:172-9
• Drazinic CM Ercan-Sencicek A Gault LM, Hisama FM, Qumsiyeh MB, Nowak NJ, Cubells JF, State MW (2005) Rapid Array-Based Genomic Characterization of a Subtle Structural Abnormality: A Patient with Psychosis and der(18)t(5;18)(p14.1;p11.23), American Journal of Medical Genetics, Part A 134:282-9
• Abelson JF, Kwan K, O'Roak B, Baek D, Stillman A, Morgan TM, Mathews CA, Pauls DL, Mladen-Roko R, Gunel M, Davs NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS, Kurlan R, SInger HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW (2005) Sequence variants in SLITRK1 are associated with Tourette syndrome. Science 310:317-320

Contact

Campus Address
Child Study Center
230 South Frontage Road
P.O. Box 207900
New Haven, CT 06520-7900

Office Address
SHM I-383

E-mail
matthew.state@yale.edu

Office Phone
203-785-4659

Fax
203-785-7560