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Want To Quit?

CENTURY
Yale University
School of Medicine
SAC-203
Connecticut
Mental Health Center
34 Park Street
New Haven, CT 06519

Phone:
203-974-7591

Fax:
203-974-7606

E-mail:
infocentury@yale.edu

Calendar

Upcoming lectures and presentations of interest to the smoking cessation community:

Biological Sciences Training Program (BSTP)

Conferences are held in room W212 (conference room on the 2nd floor) CMHC, from 3:45 to 5:15 PM, unless otherwise noted. For more information, contact Georgia Miller, 203-974-7723 or Georgia.Miller@yale.edu.

October 4 -- Chris Heath, Yale Division of Molecular Psychiatry: "Developmental nicotine exposure: Persistent behavioral effects and neurobiological mechanisms"

Prior lectures and presentations of interest to the smoking cessation community:

Informational Sessions on NicVAX

5:30PM, SATU, 1 Long Wharf Drive, New Haven

August 12 and August 16, 2010 -- We are conducting a new research study using NicVAX, an investigational vaccine for smoking cessation. Information sessions on the vaccine and the study will be presented at Yale University, SATU. Contact Susan at 203-974-7588 for more information.

The Women’s Behavioral Health Research Division

10:15 to 11:45 AM, Connecticut Mental Health Center Auditorium, 34 Park Street, New Haven

April 30, 2010 -- Visiting Lecture: Dr. Sharon Allen, University of Minnesota “Women and smoking cessation: Do hormones count?” CME Credit.

Symposium in Memory of Julie Staley

March 26, 2010 9 AM -12PM, CMHC Auditorium

Keynote Address:
(11AM) Edythe D. London, Ph.D., Professor, Departments of Psychiatry and Biobehavioral Sciences, and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA "Imaging the Biology of Nicotine Dependence from Mice to Men"

Other speakers included:
John Seibyl, M.D., Senior Investigator, Institute for Neurodegenerative Disorders
Fred Bois, Ph.D., VA Medical Center
Kelly Cosgrove, Ph.D., Assistant Professor of Psychiatry
Irina Esterlis, Ph.D., VA Medical Center
John Krystal, M.D., Professor, Department of Psychiatry

Special Topics in Clinical Psychology:

March 2 , 2010 -- Sherry McKee, Ph.D., Associate Professor of Psychiatry, Yale School of Medicine:"Why is it more difficult for women to quit smoking?"

2008 - 2009 TTURC Seminars:

August 20, 2009 -- Helen Kamens, Ph.D.: “Nicotinic acetylcholine receptors influence ethanol behaviors”

July 2, 2009 -- Yann Mineur, Ph.D.: “Molecular and cellular basis of nicotine-induced feeding modulation”

February 5, 2009 -- Maryka Quik, Ph.D., Professor and Senior Research Scientist, Parkinson’s Institute and Clinical Center, Sunnyvale, California: "Nicotinic receptors - potential therapeutic targets for Parkinson's disease"

January 23, 2009 -- Gyongyi Szabo, MD, Ph.D., Professor, Associate Dean for Clinical and Translational Research, Director of Hepatology and Liver Center at the University of Massachusetts Medical School: “Alcohol-induced regulation of inflammation and immunity”

January 8, 2009 -- Dr. Lorise Gahring, Ph.D., Department of Internal Medicine, Division of Geriatrics, University of Utah School of Medicine: “The Nicotine-Inflammation Interaction”

December 18, 2008 -- Zubin Bhagwagar MD, Ph.D.: “Nicotinic receptor dysfunction in Major Depressive Disorder: Where there is smoke...”

December 4, 2008 -- Helen Kamens MD, Ph.D.: "The involvement of nicotinic acetylcholine receptors in ethanol consumption"

November 6, 2008 -- Marc Potenza MD, Ph.D.: "Neural correlates of cognitive control and monetary processing in adolescent smokers: relationship to impulsivity and treatment outcome"

November 19, 2009 -- Meenakshi Alreja, Ph.D.: “Nicotinic Actions on Medial Prefrontal Cortical Interneurons: Implications for Schizophrenia”

Womens Behavioral Health Research Division Seminar:

Psychology Section Colloquium:

"Special Topics in Clinical Psychology," chaired by Dr, Robin Masheb and coordinated by Joan Cricca, meets on the first Tuesday of each month from 4:15 to 5:30pm at 300 George Street, Suite 901. For questions, please contact Joan Cricca at 785-2090.

April 7, 2009 -- Sherry McKee, Ph.D., Associate Professor, Dept. of Psychiatry, Yale School of Medicine:"Why is it more difficult for women to quit smoking?"

Community Services Network Training Institute

April 20, 2009 -- Stephanie O’Malley, Ph.D., Professor of Psychiatry, Yale School of Medicine, presented "State of the Art Treatment for Smoking Cessation," from 9:00am to 11:00am at the Connecticut Mental Health Center, 34 Park Street, New Haven, in Room 133.

Yale Pediatric Grand Rounds Seminar Series:

March 4, 2009 -- Dr. Jonathan Winickoff: “Third hand smoke and how to get every family member to quit smoking” Dr. Jonathan Winickoff is a practicing pediatrician and assistant professor of pediatrics at Harvard Medical School. He was the first to evaluate the delivery of smoking cessation pharmacotherapies to parents in the pediatric setting. This program known as CEASE, the Clinical Effort Against Secondhand Smoke Exposure, is being used in North Carolina and Massachusetts, and is available nationally at ceasetobacco.org. His research was recently featured in the New York Times. He has received numerous awards including the Health and Human Services Secretary's Award for Distinguished Service for "protecting the health of the United States public" and the 2008 Jarvik-Russell Young Investigator of the Year award from Society for Research on Nicotine and Tobacco. He currently chairs the American Academy of Pediatrics Tobacco Consortium. He is the Harvard site principal investigator for the Julius Richmond Center of Excellence, addressing the secondhand smoke exposure of children.

Department of Psychiatry Grand Rounds:

December 12, 2008 -- Suchitra Krishnan-Sarin, Ph.D.: “Smoking cessation among adolescents: What do we know and where do we go? ”

Biological Science Training Program Lectures:

March 16, 2009

Speaker: Evelyn Lambe, Ph.D., University of Toronto

Topic: "Nicotinic receptors and developing prefrontal attention circuitry"

November 3 , 2008

Speaker: Yann Mineur, Ph.D., Yale Dept. of Molecular Psychiatry

Topic: “Neurobiological Basis of Anorexigenic Effects of Nicotine”

June 9 , 2008

Speaker: Aybala Saricicek, Ph.D., Yale Dept. of Psychiatry

Topic: “Molecular imaging of nicotinic acetylcholine receptors in major depressive disorder”

March 31, 2008

Speaker: Peter Olausson, Ph.D., Yale Dept. of Psychiatry

Topic: “Cellular Correlates of Cognitive-Motivational Dysfunction in Animal Models of Addiction”

November 26, 2007

Speaker: Bao-Zhu Yang, Ph.D., Yale Dept. of Psychiatry

Topic: "Searching for risk variants for substance dependences in the gene cluster at chromosome 11q23"

September 17, 2007

Speaker: Yann Mineur, Ph.D., Yale Dept. of Molecular Psychiatry

Topic: "Nicotinic acetylcholine receptors and modulation of mood: Insights from animal models"

Department of Pharmacology Seminar

May 22, 2008 -- Hans Rollema, Ph.D., Department of Neuroscience, Pfizer Global Research and Development: "Rationale and design of α4ß2 nAChR partial agonists for smoking cessation: discovery and development of varenicline"

2007 - 2008 TTURC Seminars included:

March 13, 2008 -- Yann Mineur, Ph.D.: "Neurobiological Basis of Anorexigenic Effects of Nicotine"

February 7, 2008 -- Ned Cooney, Ph.D.: “Combination Nicotine Replacement for Alcohol Dependent Smokers”

January 24, 2008 -- Peter Olausson, Ph.D.: "Role of nicotinic acetylcholine receptors in reward-related learning and conditioned reinforcement - a potential target for prevention of cue-induced relapse?" PLEASE NOTE: THIS SEMINAR WAS RESCHEDULED FROM JANUARY 3.

December 6, 2007 -- Robin Mermelstein, Ph.D., Professor of Psychology, University of Illinois: “Social and Emotional Contexts of Adolescent Smoking Patterns”

November 15, 2007 -- Ray Niaura, Ph.D., Brown University: “Prenatal Tobacco Exposure: A Long and Winding Tale”

October 4, 2007 -- Yousef Tizabi, Ph.D., Howard University College of Medicine: "The Good and the Bad of Alcohol and Nicotine"

2006 - 2007 TTURC Seminars included:

September 21, 2006 -- Mehmet Sofuoglu, Ph.D. TITLE: "IV Nicotine Self-Administration in Humans"

October 5, 2006 -- No seminar

November 16, 2006 -- Jeremy Gray, Ph.D.: “Integrating Affect, Self-control, and Intelligence”

December 7, 2006 -- Benjamin Toll, Ph.D.: "Naltrexone & Bupropion to Stop Smoking with Less Weight Gain"

January 4, 2007 -- Amy Latimer, Ph.D.: “A Message Makeover: An Evaluation of Framed Smoking Cessation Videos for Adolescents”

January 16, 2007 -- Darlene Brunzell, Ph.D.:  "Molecular and neurochemical mechanisms of behaviors relevant to nicotine addiction"

February 1, 2007 -- Dana Small, Ph.D.: “Food reward as a function of smoking status”

March 1, 2007 -- Gerard Sanacora, Ph.D.: “Measurement of Cortical Excitability Following Acute Nicotine Administration in Smokers and Non-Smokers”

April 5, 2007 -- Thomas McMahon, Ph.D.: “Emotional Distress and Substance Use Among Affluent, Suburban Teens: Untangling Concurrent and Prospective Relationships”

April 19, 2007 -- David Gilbert, Ph.D.: “Characterizing the Affect-Modulating Effects of Nicotine: Vulnerability Factors and Challenges”

May 3, 2007 -- Neal Benowitz, M.D.: “Nicotine Metabolism and the Pharmacogenetics of Nicotine Addiction Treatment”

Summer 2006 Journal Club Presentations Included:

July 13th

Krystle Kuzia:

Article Title: Identifying and predicting adolescent smokers’ development trajectories (2004)

Authors: Warrant R. Stanton, Brian R. Flay, Craig R. Colder, and Paras Mehta

Kitty Chen:

Article Title: Smoking-induced ventral striatum dopamine release (2004)

Authors: Arthur Brody, Richard Olmstead, Edythe London, Judah Farahi, Jeffrey Meyer, Paul Grossman, Grace Lee, Joe Huang, Emily Hahn, and Mark Mandelkern

 July 20th

Chris Huffman:

Article Title: Precessation treatment with nicotine skin patch facilitates smoking cessation (2006)

Author: Jed Rose, Frederique Behm, Eric Westman, and Prity Kukovich

Nina Han:

Article Title: Occupancy of dopamine D2 receptors by antipsychotic drugs is related to nicotine addiction in young patients with schizophrenia (2006)

Authors: Lieuwe de Haan, Jan Booij, Jules Lavalaye, Therese van Amelsvoort, and Don Linszen

July 27th

Ellen Carson:

Article Title: Impulsivity and smoking relapse (2004)

Authors: Neal Doran, Bonnie Spring, Dennis McChargue, Michele Pergadia, and Malia Richmond

Shenelle Donovan:

Article Title: Gender: A major determinant of brain response to nicotine (2005)

Authors: James Fallon, David Keator, James Mbogori, Derek Taylor, and Steven Potkin

August 3rd

Karen Tellez-Jacques:

Article Title: Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part II: Effects of voluntary chronic alcohol consumption (2006)

Authors: Adolf Pfefferbaum, Elfar Adalsteinsson, Rohit Sood, Dirk Mayer, Richard Bell, William McBride, Ting-Kai Li, and Edith Sullivan

Lauren Hackney:

Article Title: Comparative Epidemiology of Dependence on Tobacco, Alcohol, Controlled Substances, and Inhalants: Basic Findings From the National Comorbidity Survey (2004)

Authors: James Anthony, Lynn Warner, and Ronald Kessler

Spring 2006 seminars included:

May 2 -- Robert Anthenelli, M.D., University of Cincinnati. TITLE: “Recent Developments in Treating Tobacco Dependence”

May 16 -- Yann Mineur, Ph.D., Yale University. TITLE: "Nicotinic Acetylcholine Receptors and Antidepressant-like Effects in Mice"

May 23 -- Irina Esterlis, Ph.D. Yale University. TITLE: “[123I]Iomazenil SPECT Imaging of GABAA-benzodiazepine Receptors in Healthy Smokers”

May 30 -- Andrea Weinberger, Ph.D., Yale University. TITLE: “The Role of Expectancies in a Clinical Trial of Selegiline: Baseline Data and Pilot Study Update”

2005 seminars included:

January 11 -- Dr. Dana Small, Ph.D. Dr. Small, a new faculty member at Yale and The John B Pierce Lab, studies brain substrates of food reward in humans. She hopes to investigate brain response to food and cigarette aromas in smokers, including those who gain weight and those who do not. To find out more about Dr. Small, you can read her web page. This information is from her web page, "Dana Small joined the John B. Pierce Laboratory in June, 2004 as an Assistant Fellow. She received her M.Sc. in Neuroscience in 1998 and her Ph.D. in Clinical Psychology in 2001 from McGill University in the laboratory of Dr. Marilyn Jones-Gotman. Following her graduate work she moved to Northwestern University in Chicago where she trained with Dr. Marsel-Mesulam as an Assistant Professor of Neurology. Dr. Small's research has focused upon food reward and flavor processing in the human brain using radioligand and functional neuroimaging techniques. She is a member of the Association for Chemoreception Sciences, the Organization for Human Brain Mapping, the Society for Neuroscience, and the International Neuropsychological Symposium."

February 7 -- Dr. Caryn Lerman, Ph.D., professor,Dept. of Psychiatry and director, Tobacco Use Research Center at the University of Pennsylvania. Dr. Lerman's interests include" human bio-behavioral studies employing laboratory-based methods, cohort studies, and clinical trials to investigate gene-environment interactions in nicotine dependence." For more information, please see her web page. To find out more about the work being done at the University of Pennsylvania TTURC, please see their web page.

May 10 -- Dr. Kelly Cosgrove, a postdoc fellow in psychiatry. Title: b2-nAChR availability during acute and prolonged nicotine withdrawal in tobacco smokers.

May 31 -- Derek Yach, MBChB, M.P.H. head of the Division of Global Health and Yale's School of Public Health. World No Tobacco Day. For more information about Yach, please see his web page.

2004 seminars included:

April 13 -- Dr. Sherry McKee. "Alcohol and Tobacco Interactions: Results from two lab studies & next steps". Dr. McKee, from CENTURY/TTURC, will be presenting final data from her TTURC pilot study examining alcohol-mediated tobacco relapse. She will also present preliminary findings from her lab study examining the effect of nicotine/ placebo patch on alcohol self-administration. Finally, she will discuss next steps for a June R01 submission. Brownies & milk will be provided.

April 27 -- Dr. Karen Hudmon. "Nationwide Dissemination of a Tobacco Curriculum for Students in the Health Professions." A behavioral epidemiologist and licensed pharmacist with the Yale School of Public Health, Dr. Hudmon's research focuses on smoking initiation and cessation among adolescents and young adults; methods for treating tobacco use and dependence through expansion of the clinician's role in cessation; and genetic predisposition for tobacco use and dependence. She helped develop a comprehensive tobacco cessation training program for students in the health professions. To find out more about Dr. Hudmon, you can read her web page.

May 25 -- Dr. Darlene Brunzell. Dr. Brunzell is the investigator directing the 2003 CENTURY/TTURC pilot project, "Contributions of CREB Signaling to Nicotine Dependence." The specific aims of the project are 1) to use viral vector technology to identify a functional role of nucleus accumben's CREB in nicotine conditioned place preference, 2) to discover whether CREB contributions to nicotine place preference are sexually dimorphic, and 3) to determine whether accumbens CREB signaling affects second messenger signaling in other mesocorticolimbic brain structures. These studies may be the first to provide a functional link between neurochemical changes in CREB activity and nicotine reinforcement.

June 8 -- Dr. Eve Colson. Dr. Colson is the investigator directing the 2003 CENTURY/TTURC pilot project, Designing an Intervention to Prevent Women from Returning to Smoking after Pregnancy. The purpose of the pilot project is to conduct an initial evaluation of the effectiveness and the acceptability of an intervention designed to prevent women who have quit smoking during pregnancy from relapsing after the birth of their infants as a prelude to a large-scale randomized clinical trial.

June 22 -- Dr. Joel Dubin. Yale University School of Medicine. Assistant Professor, Biostatistics, Department of Epidemiology and Public Health. The title is "Specialized Survival Graphs for Longitudinal Pharmacotherapy Smoking Cessation Trials".  Here is a description: "Prior to performing any modeling of the complex data that is produced from longitudinal studies, exploratory techniques are useful and often quite necessary to explore important patterns and relationships.  Using an application of a dose-ranging pharmacotherapy smoking cessation clinical trial, we will present specialized survival graphical methods in the exploration of patient adverse events, dropout, and dosage level.   Also, we hope to convey the utility of these graphical methods  for other longitudinal clinical trials and observational studies." Dr. Dubin's areas of specialty include methods and analysis strategy for longitudinal and survival data.

August 13 -- Dr. Benjamin Toll, Ph.D. "Interactive Voice Response (IVR) assessment of smoking,drinking, and related syndromes." The study Dr. Toll will present focuses on comparing reports of cigarette and alcohol consumption, craving, depressive symptoms, and withdrawal using an Interactive Voice Response (IVR) system, the Timeline Followback (TLFB), and several questionnaires. As part of a smoking cessation trial, daily reports of cigarette and alcohol use were collected using an IVR system and TLFB for seven days after participants attempted to quit smoking, and several research assessments (i.e., the Questionnaire on Smoking Urges, the Center for Epidemiological Studies-Depression, and the Minnesota Nicotine Withdrawal Scale) were completed on the seventh day after quitting. The sample was composed of 381 daily smokers who were not alcohol dependent. Reports of cigarette and alcohol consumption were assessed for the entire sample and for the subsets of non-abstinent participants (n=129 smokers; n=182 drinkers). Compliance with the TLFB was superior to compliance with the IVR system. Sensitivity of both assessment methods was found to be poor, but specificity of both was shown to be good. The results revealed moderate to high correlations between reports of smoking and drinking behavior as assessed by IVR and TLFB. Reporting biases for both IVR and TLFB were approximately equal. Moderate to high correlations were found between research assessments and IVR reports of craving, depressive symptoms, and nicotine withdrawal. Possibilities for future research based on the present results will be suggested.

July 13 -- Dr. Jack Elias, M.D. The Waldemar Von Zedtwitz Professor of Medicine Chief, Pulmonary and Critical Care Medicine at the Yale University School of Medicine Department of Internal Medicine, Dr. Elias' clinical interests include asthma, COPD, interstitial lung disease, acute lung injury. For more information about Dr. Elias, you can read his web page.

Sept. 21 from 4 to 5 p.m. -- Dr. Daniel McGehee, University of Chicago, Department of Anesthesia & Critical Care. Dr. McGehee's research focuses on neuronal nicotinic receptors and synaptic transmission. The title of his seminar will be  "Cellular correlates of drug abuse vulnerability" To find out more about Dr. McGehee, you can read his web page.

October 19 -- Dr. Idil Cavus, M.D., Ph.D. -- "Nicotine and brain glutamate release.  Preliminary studies in humans." Dr. Cavus is the investigator leading the CENTURY/TTURC Pilot Project, Effect of Nicotine Gum on Brain Neurochemistry and Activity in Women and Men. This study will compare the effects of nicotine gum (2 mg) to placebo on the cerebral release of glutamate, GABA, norepinephreine and dopamine in women and men using in vivo microdialysis. Also, this study will examine the effect of nicotine gum on the brain activation with analysis of intracranial EEG recordings in men and women.

Nov. 16 -- Dr. K. Michael Cummings, Ph.D., MPH.Dr. Cummings is Chair, Department of Health Behavior Division of Cancer Prevention and Population Sciences at Roswell Park Cancer Institute. "Dr. Cummings' research interests focus on the health effects of tobacco, smoking cessation and tobacco use prevention. A nationally recognized authority on smoking issues, he has contributed to several United States Surgeon General's Reports on Smoking and Health and to the Institute of Medicine's report on nicotine addiction in children. Dr. Cummings has testified as an expert witness against the tobacco industry in a number of recent legal proceedings, including several state Medicaid cases which resulted in the Master Settlement Agreement." For more information, please see his web page. He is the latest recipient of a TTURC and is coming to talk about his work in the smoking area as well as the plans for his TTURC.

Nov. 30 -- Dr. Kelly P. Cosgrove, Ph.D. Dr. Cosgove is a Postdoctoral Fellow at the Yale University School of Medicine and VA Connecticut Healthcare System, Department of Psychiatry. She will be talking about " "Morphometry, brain function and drug abuse:  a review of sex differences". 

SRNT 2004

The 2004 meeting of the Society for Research on Nicotine and Tobacco was Feb. 18 to 21 in Scottsdale, Arizona.
To find out about presentations, posters and papers by members of CENTURY/tturc, you can go to our listing of 2004 SRNT information.

For information about other past events, please see our 2003 calendar.