The GRAIL Gene Finding Program
- The most popular gene finding program is GRAIL.
- GRAIL can be accessed at http://avalon.epm.ornl.gov/Grail-bin/EmptyGrailForm.
- GRAIL works by using a neural network to combine the information from various gene finding signals:
- A neural network is an elementary model of the behavior of neurons.
- Each neuron is assumed to combine information in a linear fashion and then apply some non-linear function f:
- O = f(a0 + a1 I1 + ... + am Im)
- The parameters ai can be learned by using variants of "Hebbian" learning:
- If on some example Oi is correct and Ii is positive, increase ai and vice versa.
- Neurons can combined in a network to calculate some function:
