BBS Program
Yale University
P.O. Box 208084
New Haven, CT 06520-8084
Tel: 203.785.3735
Fax: 203.785.3734
bbs@yale.edu
Sterling Professor of Genetics
Director, Molecular Oncology & Development
B.S. Northwestern University 1950
M.D. Harvard Medical School 1955
Projects underway in our laboratory include: 1) Analysis of overall patterns
of gene expression during
myeloid differentiation and neutrophil activation. We are using a combination
of gel display and array technologies to study at the cDNA level the (nearly)
complete pattern of changes in gene expression during progression from early
myeloid precursors to mature and activated polymorphonuclear leucocytes.
2) Analysis of enhancer promoter interactions in the globin system. Studies focus
both on developmental change in globin regulation and on specific interactions
between particular enhancers and promoter elements. 3) “New” immune
functions of the major histocompatibiliy complex (MHC). We are studying genes
within the MHC that are expressed in mature dendritic cells and can cause a variety
of other cell types to assume dendritic morphology. 4) The molecular basis for
the premature aging phenotype in Werner syndrome and relationships between the
Werner gene and telomerase. Werner patients display a number of aspects of advanced
age in mid-life. Defects in the Werner helicase mimic premature aging more than
does any other single gene disorder and provide an entry to uncovering the molecular
weak points during normal aging. 5) We are continuing to explore DNA repair enzymes
and methodologic approaches to simplify detection of genetic variants associated
with diseases or particular phenotypes.
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Yale School of Medicine
Last updated
6/11/08
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