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Christian Tschudi

 

Microbiology

Professor of Epidemiology & Public Health and Internal Medicine

Education

A.B. University of Basel 1978
Ph.D. University of Basel 1982

Research Interests

Our studies focus on the biology of trypanosomes, the causative agents of devastating diseases in Africa and South America. Most projects in the laboratory utilize bioinformatics and modern genetic techniques to identify and dissect parasite-specific functions. The laboratory has developed several methodologies for creating mutants and has been instrumental in establishing a number of techniques to study processes at the biochemical level. These approaches will lead to a better understanding of the infectious cycle of the parasite, which involves a mammalian as well as an insect host. The long-term goal is to identify candidate molecules that can be targets for chemotherapy. We are also interested in understanding gene silencing by RNA interference in African trypanosomes with the objective to uncover its biological function.

Recent Publications

• Arhin, G.K., Li, H., Ullu, E., and Tschudi, C. (2006). A protein related the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei. RNA 12:53-62.
• Shi, H., Tschudi, C., and Ullu, E. (2006). An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei. RNA 12:2063-2072.

Contact

E-mail
christian.tschudi@yale.edu