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Mark J. Shlomchik

 

Immunology; Pharmacology & Molecular Medicine

Professor of Laboratory Medicine and Immunobiology

Education

B.A. Harvard University 1981
Ph.D. University of Pennsylvania 1989

Research Interests

Our lab is interested in B cell development and immunopathogenesis. One set of projects focuses on autoimmunity: how do autoreactive B cells arise and what are the role(s) that these cells play in mediating autoimmune disease? We are using transgenic and knockout mouse models to answer these questions. We have made intriguing discoveries on the roles of Toll-like receptors in systemic autoimmunity and are following up on these. A second project addresses B cell activation and memory. We have made recent insights, including via in vivo multiphoton microscopy, into the mechanisms of cellular selection and differentiation in the germinal center, a site of rapid proliferation, mutation, and differentiation into memory cells. We have identified novel memory-specific genes and are studying their roles using KO mice and in vitro signaling assays. Finally, we are investigating why memory T cells fail to cause graft-vs-host disease using a new TCR Tg model.

Links

• Shlomchik Homepage

Recent Publications

• Anderson, S.M., Hannum, L.G., and Shlomchik, M.J. (2006). Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells. J. Immunol. 176:4515-4519.
• Christensen, S.R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R.A., and Shlomchik, M.J. (2006). Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25:417-428.

Contact

E-mail
mark.shlomchik@yale.edu