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Craig R. Roy

 

Microbiology; Immunology

Professor of Microbial Pathogenesis

Education

Ph.D. Stanford University 1991

Research Interests

The focus of our research is to understand the molecular and cellular events that enable microbial pathogens to evade host defense mechanisms. In particular, we are interested in how bacteria that replicate inside mammalian cells create specialized vacuoles that support pathogen replication. We have been using Legionella pneumophila and Coxiella burnetii as model pathogens to study this process. We have been characterizing a type IV secretion system called Dot/Icm that delivers bacterial effector proteins into the eukaryotic host cell cytosol. The goals of this research are to determine the mechanism by which these bacterial effector proteins regulate phagosome maturation, modulate host immunity, and subvert eukaryotic cell functions.

Curriculum Vitae & Links

• Roy Homepage

Recent Publications

• Pan X, Lührmann A, Satoh A, Laskowski-Arce MA, Roy CR. (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320:1651-1654.
• Ingmundson A, Delprato A, Lambright DG, Roy CR. (2007). Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature 450:365-9.

Contact

E-mail
craig.roy@yale.edu