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Carla V. Rothlin

 

Immunology

Assistant Professor of Immunology

Education

Ph.D. University of Buenos Aires, 2002

Research Interests

Inflammation - the response elicited by injury and recognition of foreign antigens - involves a complex interplay of biochemical pathways that trigger and shape the immune response. These culminate in a coordinated response that is essential for protection against invading pathogens. Its fundamental role notwithstanding, inflammation, if unchecked, can favor the development of chronic inflammatory and autoimmune diseases. Thus, mechanisms that regulate its duration and intensity are fundamental to immune homeostasis. Our research interest is to elucidate the mechanisms that underlie the regulation of inflammation and the homeostatic control of immune function. We have discovered a signaling pathway downstream of the TAM (Tyro3, Axl, Mer) receptor tyrosine kinases that limits the amplitude and phase of the inflammatory response. We are currently focusing on identifying the in vivo source of TAM ligands, unraveling the molecular determinants that account for the specificity of TAM-mediated inhibition, decoding the transcriptome activated during TAM-mediated inhibition of inflammation, and testing the role of TAM-mediated immune suppression in vivo, employing established animal models of chronic inflammatory and infectious diseases. Our long-term goal is to specifically manipulate this pathway as an innovative therapeutic strategy for the inhibition or enhancement of the inflammatory response.

Recent Publications

• Rothlin C.V, Ghosh S., Zuniga E., Oldstone M.B., Lemke G.E (2007). TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131(6): 1124-1136.
• Lemke G and Rothlin C.V. (2008). Immunobiology of the TAM receptors. Nat Rev Immunol 8(5): 327-336

Contact

E-mail
carla.rothlin@yale.edu