• Calendar
• A-Z Index

Pasko Rakic

 

Neuroscience

Dorys McConnell Duberg Professor of Neuroscience
Professor and Chairman of Neurobiology

Education

M.D. Belgrade University 1959
D.Sc. Belgrade University 1969

Research Interests

Research in this laboratory is focused on developmental neurobiology, more specifically on the mechanism of neuronal proliferation, migration, programmed cell death, axonal guidance, and patterns of synaptic connectivity and their plasticity during development of the central nervous system. One line of investigation focuses on the interaction between neuronal and glial cells during neuronal migration, the effects of various epigenetic factors on the development of structural, molecular and functional cell phenotypes, and their segregation into topographic maps. Other research concerns the differentiation, synaptogenesis, and emergence of transmitters and their receptors in laminated structures (cerebellum, hippocampus, neocortex). Special emphasis has been on normal and experimentally altered development of the visual system following selective destruction of visual centers and/or pathways in developing primates. A battery of the most advanced methods are used with the hope of gaining insight into epigenetic sequences and the cellular and molecular mechanisms that regulate the development and evolution of the primate brain.

Links

• Rakic Homepage

 

Recent Publications

• Hoglinger, G.U., et al. (2007). The pRb/E2F cell-cycle pathway mediates cell death in Parkinson?fs disease. Proc. Natl. Acad. Sci. (USA) 104(9):3585-90.
• Burns, K.A., et al. (2007). Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral Ischemia-Hypoxia. Cereb. Cortex Jan 27.

Contact

E-mail
pasko.rakic@yale.edu