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Jordan S. Pober

 

Pharmacology & Molecular Medicine; Immunology

Professor and Vice Chair of Immunobiology for Human and Translational Immunology

Professor of Pathology and Dermatology

Education

B.A. Haverford College 1971
M.D., Ph.D. Yale University 1977

Research Interests

Our research addresses three interrelated problems in the immunobiology and pathology of vascular endothelial cells. First, we examine and analyze the consequences that ensue when human T lymphocytes recognize specific antigens presented by human or porcine vascular endothelial cells in comparison to recognition of antigens presented by professional antigen presenting cells or by tissue cells (e.g., fibroblasts, vascular smooth muscle, etc). Second, we examine the signaling pathways activated by T cells or their products (e.g., cytokines) and the transcriptional regulation of cytokine-induced molecules, such as leukocyte adhesion molecules, within vascular endothelial cells. Third, we analyze the pathways of cell injury (e.g., apoptosis) in vascular endothelial cells induced by leukocytes and their products as well as responses made by endothelial cells to resist such injury. Our experimental approaches involve use of normal and genetically-modified (i.e., transfected) cell populations in culture, use of chimeric animals, (e.g., immunodeficient mice doubly engrafted with human or pig blood vessels and with human lymphocytes), and use of discarded human tissues from control and disease settings. These studies may lead to novel, endothelial-directed therapies for modifying immune and inflammatory diseases. A particular focus of our work is on modifying the behavior of endothelial cells to improve outcomes of clinical transplantation and tissue engineering.

Recent Publications

• Choy, J.C., Wang, Y., Tellides, G., and Pober, J.S. (2007). Induction of iNOS in bystander human T cells increases allogeneic responses in the vasculature. Proc. Natl. Acad. Sci. (USA) 104:1313-1318.
• Shepherd, B.R., Enis, D.R., Wang, F., Suarez, Y., Pober, J.S., and Schechner, J.S. (2006). Vascularization and engraftment of a human skin equivalent using circulating progenitor cell-derived endothelial cells. FASEB J. 20:1739-1741.

Contact

E-mail
jordan.pober@yale.edu