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Michael H. Nathanson

 

Molecular Cell Biology, Genetics & Development

Professor of Medicine and Cell Biology

Education

B.S. University of California, Berkeley 1976
M.D., Ph.D. Case Western Reserve University 1985

Research Interests

My laboratory is interested in the mechanisms and effects of calcium signals in polarized epithelia. One aspect of this work is to define how calcium signals are differentially regulated in the nucleus and cytoplasm. This involves identification of distinct calcium stores and release mechanisms in the nucleus, and we are examining whether and how these are activated selectively by growth factors. Long-range plans are to determine the relative effects of nuclear and cytoplasmic calcium signals on cell growth. The second aspect of our work is to examine how calcium waves and other types of calcium signals regulate secretion in polarized epithelia. Calcium waves preferentially begin in the apical region of most secretory epithelia, and we are in the process of defining the mechanisms responsible for this. We also are using an adenoviral antisense approach to understand the relative roles of each inositol 1,4,5-trisphosphate receptor isoform in regulating calcium signaling in secretion in vitro and in vivo. The long-range goal of all of these studies is to determine how the spatial organization of calcium signals regulates organ function, and to examine whether altered calcium signaling patterns are responsible for impaired tissue regeneration secretion in certain disease states.

Links

• Nathanson Homepage

Recent Publications

• O’Brien, E.M., Gomes, D.A., Sehgal, S., and Nathanson, M.H. (2007). Hormonal regulation of nuclear permeability. J. Biol. Chem. 282:4210-4217.
• Hernandez, E., et al. (2007). The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves. J. Biol. Chem. 282:10057-67.

Contact

E-mail
michael.nathanson@yale.edu