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Joseph A. Madri

 

Pharmacology & Molecular Medicine; Molecular Cell Biology, Genetics & Development

Professor of Pathology

Education

B.S. St. John's University, NY 1967
M.D., Ph.D. Indiana University 1975

Research Interests

Endothelial cells play central roles in development and maintenance of the vascular system and in the processes of inflammation and metastasis. Interactions with cell adhesion molecules, surrounding matrix, and soluble factors directs endothelial cell responses; yet little is known about these complex interactions and the mechanisms involved in signal transduction. Specifically, we are investigating the roles of homotypic and heterotypic cell adhesion molecules, integrins, junction associated molecules, and extracellular matrix components in modulating vascular development and behavior. We are also investigating neural stem cell-endothelial cell interactions and the roles of T-cell and endothelial cell proteinases and proteinase inhibitors in modulating T-cell transendothelial migration and their roles in initiating and maintaining the inflammatory response in murine models of autoimmune disease and in several tissue culture models. A multi-disciplinary approach is used which includes the use of knockouts, transgenics, tissue and embryo culture model systems of cell adhesion, migration, and angiogenesis.

Links

• Madri Homepage

Recent Publications

• Zhang, J., Biswas, P., Li, P., Kelm, R., Kashgarian, M., and Madri, J.A. (2007). PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells. J. Cell. Physiol. 210(2):527–537.
• Li, Q., Ford, M., Lavik, E., and Madri, J.A. (2006). Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells - an in vitro study, J. Neurosci. 84(8):1656-68.

Contact

E-mail
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