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Susan Kaech

 

Immunology; Microbiology

Assistant Professor of Immunobiology

Education

B.S. University of Washington 1993
Ph.D. Stanford University 1998

Research Interests

Memory T and B cells constitute our primary system of defense against reoccurring infectious disease, and therefore, the ability to form these cells is the ultimate goal of vaccination. My laboratory is interested in understanding how memory T cells are generated during infection and vaccination, and why in some circumstances, certain immunizations fail to induce long-term T cell immunity. Using several powerful model systems of infection in mice, we are beginning to elucidate the mechanisms involved in the development of protective and long-lived memory T cells. Our studies are primarily aimed at identifying the signals that regulate the differentiation of naïve CD8 T cells into effector cells and then into long-lived memory cells during the viral and bacterial infections of lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes in mice.

Links

• Kaech Homepage

Recent Publications

• Chandele, A. and Kaech, S.M. (2005). Memory CD8 T cell maturation occurs independently of CD8aa. J. Immunol. 175:5619-5623.
• Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., and Ahmed, R. (2003). Selective expression of the IL-7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunol. 4:1191-98.

Contact

E-mail
susan.kaech@yale.edu