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Yung-chi Cheng

 

Pharmacology & Molecular Medicine; Microbiology

Henry Bronson Professor of Pharmacology

Education

B.S. Tunghai University 1966
Ph.D. Brown University 1972

Research Interests

Our laboratory focuses on cancer and viral chemotherapy. We are studying the functional roles and properties of virus-specific proteins in order to design selective antiviral compounds. Some anti-HIV drugs have selective action against mitochondrial DNA synthesis that could lead to toxicity. This observation offered the opportunity to develop new antiviral drugs without such side effects and to examine the role of mitochondrial DNA synthesis in nuclear DNA synthesis. A new class of biological active nucleoside analogs, L(-)nucleosides were discovered. Drug resistance is a critical issue in cancer chemotherapy. Our laboratory is interested in exploring the mechanisms of drug resistance development, with a special emphasis on the process involved in DNA topoisomerase, targeting drugs and nucleoside analogs. The gene regulator and the inhibitors may not only have use as cancer chemotherapeutic agents, but also in controlling the development of drug resistance. Several novel compounds targeting on NF-KB were discovered by my laboratory and are currently being studied. To explore Chinese medicine for current clinical usage is also pursued.

Recent Publications

• Hsu, C., et al. (2007). Comparison of phosphorylation of 4?f-Ethynyl 2?f, 3?f-dihydro-3?f-deoxythymidine with other anti-HIV Thymidine analogs. Antimicrob. Agents Chemother. 51 May.
• Lam, W., Park, S.-Y., Leung, C.-H., and Cheng, Y.-C. (2006). Apurinic?/?apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (Troxacitabine and beta-L-2?f,3?f-Dideoxy- 2?f,3?f-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcitabine and beta-D-arabinofuranosylcytosine). Molec. Pharm. 69(5):1607-1614.

Contact

E-mail
yccheng@yale.edu