BBS Program
Yale University
P.O. Box 208084
New Haven, CT 06520-8084
Tel: 203.785.3735
Fax: 203.785.3734
bbs@yale.edu
Professor of Pediatrics, Epidemiology & Public Health, and Microbial Pathogenesis
B.A. Brown University 1984
M.D. Georgetown University 1988
Our laboratory studies the molecular pathogenesis of parasitic diseases that affect children in developing countries. Much of this work has focused on bloodfeeding hookworms, intestinal nematodes that infect over one billion people worldwide. Using molecular, immunological, and biochemical techniques, we aim to isolate and characterize specific hookworm virulence factors that play a role in parasite survival and disease pathogenesis. Ultimately, these hookworm factors represent novel targets for a vaccine-based strategy aimed at reducing the ability of adult hookworms to feed on blood. We are also engaged in field studies in Latin American and Africa aimed at characterizing human immune responses to intestinal nematode infections, as well as developing novel molecular methods for diagnosis and monitoring of control programs. Collaborative projects include studies of the antithrombotic mechanisms of bloodfeeding arthropods. The goal of this work is to characterize the role of parasite antithrombotics in the transmission of vector borne diseases.
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Yale School of Medicine
Last updated
5/26/08
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