Roland Baron Professor of Orthopedics and Cell Biology » Molecular Cell Biology, Genetics and Development » B.S. University of Paris 1962; D.D.S. 1968; Ph.D. 1972 The laboratory studies molecular aspects of the development and maintenance of the skeleton. Project groups focus primarily on different aspects of signal transduction that regulate cell function during these processes. These include analysis of the signaling mechanisms that are activated by seven transmembrane G protein-coupled receptors, receptor tyrosine kinases, and integrins and the role of the nonreceptor tyrosine kinase Src and its interaction with the proto-oncogene c-Cbl. Other projects involve characterizing the functions of transcription factors during skeletal development and osteoblast/adipocyte differentiation. Miyazaki, T., Sanjay, A., Horne, W.C., and Baron, R. (2004). Src kinase activity is essential for osteoclast functions. J. Biol. Chem. 279:17660-17666. Kveiborg, M., et al. (2004). Delta FosB induces osteosclerosis and decreases adipogenesis by two independent cell autonomous mechanisms. Mol. Cell Biol. 24:2820-30.